If it’s your first time in Denver, Lower Downtown (or LoDo as it’s sometimes referred to) is right in the thick of things. You’ll find a myriad of bars, shops, hotels, attractions and restaurants all within walking distance, making it a super convenient home base. If, however, you’re drawn to arty hubs peppered with industrial-chic breweries, art galleries and boutique lodgings, check out RiNo (River Arts North). If you’re looking for luxury, Cherry Creek is it.